- Postdoctoral Research Associate, King’s College London
Job ID: 026485
Salary: £39,345 – £42,652, including London Weighting Allowance
Department: Randall Centre for Cell and Molecular Biophysics
Investigation on RNA binding properties of disordered unconventional RNA binding motifs
Applications are invited for a postdoctoral scientist to investigate the mechanisms of RNA binding mediated by disordered regions lacking conventional RNA binding annotations in the laboratory of Professor Maria R (Sasi) Conte, Randall Centre for Cell and Molecular Biophysics, King’s College London.
Our lab specialises in understanding the detailed mechanisms of interaction between proteins and RNA, with a major focus on the La-related proteins (LARPs). We use a combination of structural biology, biophysics and biochemistry techniques and work closely with interdisciplinary collaborators to test hypotheses in the context of cell biology and model organisms.
WE ARE LOOKING FOR
A skilled, motivated and enthusiastic postdoctoral candidate with a strong interest in protein-RNA interactions and biophysics. The project will focus on the LARPs involved as key regulators of gene expression via a variety of mechanisms.
The successful applicant will find themselves working in a dynamic, interdisciplinary and exciting research environment and will be based in the Randall Centre on the Guy’s Campus, London, UK. The project will be supported by the state-of-the-art infrastructure of the Centre for Biomolecular Spectroscopy and the Randall Centre.
The successful candidate will have most of the following characteristics:
- A Ph.D. degree in biophysics, biochemistry, structural biology or related field
- Experience in NMR spectroscopy of proteins and/or RNA
- Demonstrated proficiency in a range of biophysical and structural biology techniques (e.g. CD, fluorescence spectroscopy, EMSA, titration calorimetry, mass spectrometry, SAXS, X-ray crystallography)
- The ability to perform, interpret and integrate the results of biophysical and biochemical experiments
- Proficiency in molecular biology and protein expression and purification
- The ability to adapt, develop and implement methods as dictated by the progress of the investigations
- Prior expertise in SAXS/SANS would be highly advantageous
- Experience in intrinsically disordered proteins would be a plus
- The capability to plan and execute experimental work without close supervision
- The ability to work as part of a team
There is no expectation that candidates have experience in all these fields, and training will be provided.
This is a new position funded by the Leverhulme Trust and is available immediately.
This post will be offered on a fixed-term contract for 12 months with possibility for further extension for a further 2 years.
This is a full-time post – 100% full time equivalent.
Contact details: Professor Sasi Conte, firstname.lastname@example.org / +44 (0)20 7848 6194.
Closing date: 21-Jul-2021 in the first instance.