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  1. Postdoctoral Research Associate, King’s College London

    Job ID: 026485
    Salary: £39,345 – £42,652, including London Weighting Allowance
    Department: Randall Centre for Cell and Molecular Biophysics
    Guy’s Campus    

    Investigation on RNA binding properties of disordered unconventional RNA binding motifs

    Applications are invited for a postdoctoral scientist to investigate the mechanisms of RNA binding mediated by disordered regions lacking conventional RNA binding annotations in the laboratory of Professor Maria R (Sasi) Conte, Randall Centre for Cell and Molecular Biophysics, King’s College London.

    ABOUT US 

    Our lab specialises in understanding the detailed mechanisms of interaction between proteins and RNA, with a major focus on the La-related proteins (LARPs). We use a combination of structural biology, biophysics and biochemistry techniques and work closely with interdisciplinary collaborators to test hypotheses in the context of cell biology and model organisms.

    WE ARE LOOKING FOR  

    A skilled, motivated and enthusiastic postdoctoral candidate with a strong interest in protein-RNA interactions and biophysics. The project will focus on the LARPs involved as key regulators of gene expression via a variety of mechanisms.

    The successful applicant will find themselves working in a dynamic, interdisciplinary and exciting research environment and will be based in the Randall Centre on the Guy’s Campus, London, UK. The project will be supported by the state-of-the-art infrastructure of the Centre for Biomolecular Spectroscopy and the Randall Centre.

    REQUIREMENTS

    The successful candidate will have most of the following characteristics:

    • A Ph.D. degree in biophysics, biochemistry, structural biology or related field
    • Experience in NMR spectroscopy of proteins and/or RNA
    • Demonstrated proficiency in a range of biophysical and structural biology techniques (e.g. CD, fluorescence spectroscopy, EMSA, titration calorimetry, mass spectrometry, SAXS, X-ray crystallography)
    • The ability to perform, interpret and integrate the results of biophysical and biochemical experiments
    • Proficiency in molecular biology and protein expression and purification
    • The ability to adapt, develop and implement methods as dictated by the progress of the investigations
    • Prior expertise in SAXS/SANS would be highly advantageous
    • Experience in intrinsically disordered proteins would be a plus
    • The capability to plan and execute experimental work without close supervision
    • The ability to work as part of a team

    There is no expectation that candidates have experience in all these fields, and training will be provided.

    This is a new position funded by the Leverhulme Trust and is available immediately.

    This post will be offered on a fixed-term contract for 12 months with possibility for further extension for a further 2 years.

    This is a full-time post – 100% full time equivalent.

    Contact details: Professor Sasi Conte, sasi.conte@kcl.ac.uk / +44 (0)20 7848 6194.

    Closing date: 21-Jul-2021 in the first instance.  

    Apply link: https://jobs.kcl.ac.uk/gb/en/job/026485/Postdoctoral-Research-Associate-in-Randall-Centre-for-Cell-and-Molecular-Biophysics

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