Job offers

  • Postdoctoral Research Assistant (3 years), Queen Mary University

    Job ID: QMUL26057
    Salary: £34,733 – £40,797 per annum (Grade 4)
    Department: Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute
    Closing dat
    e: 22 Oct 2021

    Applications are sought for a Postdoctoral Research Assistant to undertake research in collaboration with and under the supervision of the Principal Investigator Dr Faraz Mardakheh for a Medical Research Council funded research project to study the role of RNA localisation in cancer. The research will be based in the Centre for Cancer Cell and Molecular Biology, Barts Cancer Institute, Queen Mary University of London (QMUL).

    Essential requirements for this post include a PhD in a relevant biological subject and an undergraduate degree in a medical/biological subject. Significant research laboratory experience in RNA biology, microscopy, as well as cell & molecular biology is essential. Additional experience in next-generation sequencing and proteomics would be an advantage. A demonstrable ability of good scientific communication, working within a scientific team, and maintaining good laboratory records is also essential.

    For information about the Mardakheh research group please visit http://mardakhehlab.info/

    Contact details: Dr Faraz Mardakhehf.mardakheh@qmul.ac.uk / +44 (0) 020 7882 8145.

    Apply link: https://webapps2.is.qmul.ac.uk/jobs/job.action?jobID=6220

  • Postdoctoral Research Assistant (3 years), University of Edinburgh

Group: Professor Javier F. Caceres
Job ID: 1889
Salary: £34,304 – £40,927 per annum
Department: MRC Human Genetics Unit, Institute of Genetics and Cancer
Closing date: 27 Oct 2021

We have one Postdoctoral research opportunity working within the laboratory of Professor Javier F. Caceres at the MRC Human Genetics Unit in Edinburgh, funded by the Medical Research Council.

Background

Our research focuses on the role of RNA-binding proteins (RBPs) in the regulation of gene expression at the post-transcriptional level. We are particularly interested in understanding how alterations to the RNA processing cascade contribute to human disease.

Research objectives

We have recently identified a localized Nonsense-mediated decay (NMD) response that regulates the expression of transcripts translated at the Endoplasmic reticulum (ER), which we termed ER-NMD (1). We aim to investigate the mechanism of ER-NMD, identify the role of ER-localized and canonical NMD factors and define the kinetics of NMD degradation of transcripts translated at the ER. We will also focus on the physiological role of this ER-localized pathway, as well as on the biological consequences of manipulating its activity in relation to cellular stress and its impact on human disease. There is also the possibility of focusing on complementary projects on the role of DExH/D RNA helicases in Alternative splicing and NMD.

Qualifications required

Prospective candidates should hold a Ph.D. (or near completion) or equivalent in a relevant science subject and have proven previous experience in molecular and cell biology and biochemistry with a keen interest in RNA biology and Gene expression. The Human Genetics Unit has facilities and expertise in a wide range of disciplines; more information on the research in the Unit can be found at http://www.ed.ac.uk/mrc-human-genetics-unit

Further details of the Research group’s workare available at:
http://www.ed.ac.uk/mrc-human-genetics-unit/research/caceres-group

For more information and to submit an application, please visit the University of Edinburgh’s website via the below link.
https://elxw.fa.em3.oraclecloud.com/hcmUI/CandidateExperience/en/sites/CX_1001/job/1889/?utm_medium=jobshare



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