- A postdoctoral position is available to work on a Wellcome Trust funded project to investigate the molecular mechanisms of regulation of alternative pre-mRNA splicing in the group of Chris Smith, Department of Biochemistry, University of Cambridge (https://www.bioc.cam.ac.uk/research/uto/smithc).
The project focuses on the mechanisms by which regulatory RNA binding proteins, such as PTBP1 and RBPMS control splicing complex assembly at regulated splice sites, and builds upon our recent discovery of RBPMS as a master splicing regulator that acts in smooth muscle cells. It will involve a range of biochemical, molecular, proteomic, biophysical, structural and single-molecule techniques based in the PI’s and collaborators labs. Candidates should have experience in two or more of the following areas: structural biology, biophysical analyses of protein-protein or protein-nucleic acid assemblies, molecular cell biology, pre-mRNA splicing/RNA biology, and bioinformatics.
The successful candidate will work in a research team comprising further post-doctoral researchers and Ph.D. students. They will need to have the initiative to work independently and as part of a team. The research will involve interaction with collaborators groups so good communication and interpersonal skills are required. In addition to carrying out research they will be expected to present research findings, contribute to writing manuscripts and supervise students in the laboratory.
The successful candidate will have a PhD or has recently submitted for a PhD.
Fixed-term: The funds for this post are available for 5 years in the first instance.
To apply online for this vacancy and to view further information about the role, please visit: http://www.jobs.cam.ac.uk/job/17208. This will take you to the role on the University’s Job Opportunities pages. There you will need to click on the ‘Apply online’ button and register an account with the University’s Web Recruitment System (if you have not already) and log in before completing the online application form.
Interested candidates are welcome to make informal enquiries to
Closing date: 23 July, 2018
- Postdoctoral Research Associate in ‘Elucidating The Role of Cellular RNA-binding Proteins in Virus Infection’
We are seeking to appoint a Postdoctoral Research Associate to elucidate, on a proteomewide scale, the cellular players interplaying with viral RNA in infected cells. This project involves the development of new high-throughput methods to study protein-RNA interactions using the latest proteomics and RNA sequencing platforms. Moreover, we will employ state-of-the-art virology and RNA biology techniques to characterise these interactions in depth.
Applicants should possess a PhD/DPhil, or be near completion of a PhD/DPhil, in biochemistry, molecular biology or related discipline and should have experience in molecular and cellular biology. You should be able to design effective experiments and be able to interpret the results accordingly. Problem-solving abilities and the capacity to drive a research project forward in a pro-active manner are essential as is the ability to work as part of a team. You should be willing to work with category 2 and 3 viruses and supervise and train students. You should have at least one publication as first author in a peerreviewed journal and be willing to apply for postdoctoral fellowships
The closing date for applications is 12.00 noon on Monday 9 July 2018, with interviews for shortlisted candidates to be held as soon as possible thereafter. Do not hesitate to contact us for further information on this post.
APPLICATION SITE: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.display_form
Dr. Alfredo Castello,
Department of Biochemistry, University of Oxford University of Oxford, firstname.lastname@example.org
Prof. Shabaz Mohammed,Departments of Biochemistry and Chemistry, University of Oxford.
- PhD Studentship, Queen Mary University of London (Closing date: 9th May 2018)“Computational multi-omics for understanding the functional impact of alternative splicing in human cancer”
We are seeking an outstanding individual with a passion for devising novel computational solutions to data-rich bioscience problems, to help us make a transformational change in our understanding of the functional impact of alternative pre-mRNA splicing in human cancer. Cancer represents a significant public health problem worldwide. Large scale consortia-led “omics” studies have facilitated a better understanding of pan-cancer genomes, transcriptomes, and proteomes. However, studies integrating pan-cancer omics datasets have been lacking, and this has limited how, for example, misregulation of transcriptomes impacts on proteomic diversity and influences human cancer phenotypes. Alternative pre-mRNA splicing (AS) is a ubiquitous genetic process that results in the “shuffling” of coding and non-coding information in the genome, creating proteomic diversity. Recently, global misregulation of AS has been associated with cancer phenotypes due to changes both within tumour cells and the microenvironment, but little is known of the global impact on pan-cancer proteomes. The aim of this project is to devise, implement and apply novel proteomics informed by transcriptomics (PIT) methodology to integrate human pan-cancer transcriptomics and proteomics data. The project will be supervised by Conrad Bessant (Professor of Bioinformatics, School of Biological and Chemical Sciences) and Dr Prabhakar Rajan (Clinical Senior Lecturer in Urology, Barts Cancer Institute and Consultant Urologist, Barts Health NHS Trust). The project will provide the student with a unique opportunity to gain valuable computational and translational research training, and will yield novel insights into cancer biology, biomarkers and therapies. For further details, please see: